product name Omeprazole
Description: Omeprazole is a proton pump inhibitor with an IC50 of 5.8 μM, it is used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome. Omeprazole. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton pump inhibitor and as such blocks the release of stomach acid.
References: J Biol Chem. 1997 May 9;272(19):12705-13; Am J Physiol. 1994 Apr;266(4 Pt 1):G745-58.
345.42
Formula
C17H19N3O3S
CAS No.
73590-58-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 69 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: 13 mg/mL (37.6 mM)
Solubility (In vivo)
2% DMSO+30% PEG 300+ddH2O: 5mg/mL
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19396608
| In Vitro |
In vitro activity: Omeprazole potently induces cytochrome P4501A1 mRNA expression in primary human hepatocytes, whereas this effect is not detected in mouse primary hepatocytes. Omeprazole induces transcription of reporter genes via the xenobiotic response element that is recognized by the ligand-activated dioxin receptor in human hepatoma cells. Omeprazole causes a strong inhibition of basal natural killer (NK) activity in spleen cells (SC) from untreated CD2F1 mice. Omeprazole causes a rapid, strong effect on various types of cytotoxic lymphocytes ranging from cytotoxicity inhibition to irreversible cell damage. Omeprazole induces a significant inhibition of cytotoxic activity of all types of effector cells after 30 min incubation. Omeprazole decreases the activation ofosteoclasts but increases that of osteoblasts in vitro, in part causing an osteopetrosis-like effect. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Omeprazole blocks H(+)-K(+)-ATPase, thus enhances degeneration and macrophage-mediated elimination of parietal cells and also causes an increase in preparietal cell production. Omeprazole temporarily changes the dynamic features of parietal cells in the rabbit to make them die early and grow fast. |
| Animal model | |
| Formulation & Dosage | |
| References | J Biol Chem. 1997 May 9;272(19):12705-13; Am J Physiol. 1994 Apr;266(4 Pt 1):G745-58. |
Related Posts
product name Omeprazole
Description: Omeprazole is a proton pump inhibitor with an IC50 of 5.8 μM, it is used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome. Omeprazole. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton pump inhibitor and as such blocks the release of stomach acid.
References: J Biol Chem. 1997 May 9;272(19):12705-13; Am J Physiol. 1994 Apr;266(4 Pt 1):G745-58.
345.42
Formula
C17H19N3O3S
CAS No.
73590-58-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 69 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: 13 mg/mL (37.6 mM)
Solubility (In vivo)
2% DMSO+30% PEG 300+ddH2O: 5mg/mL
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19396608
| In Vitro |
In vitro activity: Omeprazole potently induces cytochrome P4501A1 mRNA expression in primary human hepatocytes, whereas this effect is not detected in mouse primary hepatocytes. Omeprazole induces transcription of reporter genes via the xenobiotic response element that is recognized by the ligand-activated dioxin receptor in human hepatoma cells. Omeprazole causes a strong inhibition of basal natural killer (NK) activity in spleen cells (SC) from untreated CD2F1 mice. Omeprazole causes a rapid, strong effect on various types of cytotoxic lymphocytes ranging from cytotoxicity inhibition to irreversible cell damage. Omeprazole induces a significant inhibition of cytotoxic activity of all types of effector cells after 30 min incubation. Omeprazole decreases the activation ofosteoclasts but increases that of osteoblasts in vitro, in part causing an osteopetrosis-like effect. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Omeprazole blocks H(+)-K(+)-ATPase, thus enhances degeneration and macrophage-mediated elimination of parietal cells and also causes an increase in preparietal cell production. Omeprazole temporarily changes the dynamic features of parietal cells in the rabbit to make them die early and grow fast. |
| Animal model | |
| Formulation & Dosage | |
| References | J Biol Chem. 1997 May 9;272(19):12705-13; Am J Physiol. 1994 Apr;266(4 Pt 1):G745-58. |