product name Nimesulide
Description: Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM. Nimesulide is classified as a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is used for the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. It works by blocking the production of prostaglandins (a chemical associated with pain) thereby relieving pain and inflammation.
References: Curr Med Res Opin. 2006 Jun;22(6):1161-70; Clin Pharmacokinet. 1998 Oct;35(4):247-74.
308.31
Formula
C13H12N2O5S
CAS No.
51803-78-2
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 62 mg/mL (201.1 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19407959
| In Vitro |
In vitro activity: Nimesulide is a selective COX-2 inhibitor used in a variety of inflammatory, pain and fever states. After healthy volunteers received oral nimesulide 100 mg in tablet, granule or suspension form the drug was rapidly and extensively absorbed. Mean peak concentrations (Cmax) of 2.86 to 6.50 mg/L were achieved within 1.22 to 2.75 hours of administration. Nimesulide is an NSAID which exerts its analgesic, anti-inflammatory and antipyretic activities thanks to unique chemical and pharmacokinetic characteristics, and to a multifactorial mechanism of action, which goes beyond its preferential inhibitory activity on the COX-2 enzyme. Nimesulide was found to be at least as effective, or superior, to placebo and other NSAIDs, with a particularly fast onset of analgesic action. nimesulide remains an effective and safe therapeutic choice for the treatment of various painful inflammatory conditions, with a rapid onset of analgesic activity and an overall positive benefit/risk profile. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Curr Med Res Opin. 2006 Jun;22(6):1161-70; Clin Pharmacokinet. 1998 Oct;35(4):247-74. |
