product name Nateglinide
Description: Nateglinide (also known as A-4166) is an orally available antihyperglycemic used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of theβ cells. This depolarizes the β cells and causes voltage-gated calcium channels to open. The resulting calcium influx induces fusion of insulin-containing vesicles with the cell membrane, and insulin secretion occurs.
References: Expert Opin Pharmacother. 2011 Sep;12(13):2097-106.
317.42
Formula
C19H27NO3
CAS No.
105816-04-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 63 mg/mL (198.5 mM)
Water: <1 mg/mL
Ethanol: 63 mg/mL (198.5 mM)
Solubility (In vivo)
Synonyms
A-4166
other peoduct :
| In Vitro |
In vitro activity: Kinase Assay: Cell Assay: |
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