product name Naringin
Description: Naringin (also known as Naringoside) is a flavanone glycoside analog that exerts a wide range of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes. It inhibits hepatic P-glycoprotein (P-gp) and some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions.
References: Life Sci. 1999;65(24):2591-602; J Nutr. 2006 Jun;136(6):1477-82.
580.53
Formula
C27H32O14
CAS No.
10236-47-2
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 116 mg/mL (199.8 mM)
Water: 2 mg/mL (9.1 mM)
Ethanol: 2 mg/mL (3.4 mM)
Solubility (In vivo)
Synonyms
Naringoside
other peoduct :
| In Vitro |
In vitro activity: Naringin (also known as Naringoside) is a flavanone glycoside analog that exerts a wide range of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes. Naringin is the substance that gives the grapefruit juice its bitter taste.It inhibits hepatic P-glycoprotein (P-gp) and some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions. Naringin is also an inhibitor of vascular endothelial growth factor (VEGF) release, which causes angiogenesis. In addition, Naringin reduces diabetes-induced neuropathy in rats. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Naringin reduces diabetes-induced neuropathy in rats. |
| Animal model | |
| Formulation & Dosage | |
| References | Life Sci. 1999;65(24):2591-602; J Nutr. 2006 Jun;136(6):1477-82. |
