product name Naringenin
Description: Naringenin (also know as NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural flavanone extracted from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. Naringenin is the predominant flavanone in grapefruit. This substance has also been shown to reduce oxidative damage to DNA in vitro. .
References: JCarcinogenesis. 1990 Dec;11(12):2275-9; Diabetes Obes Metab. 2008 Nov;10(11):1097-104.
272.25
Formula
C15H12O5
CAS No.
480-41-1
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 54 mg/mL (198.3 mM)
Water: <1 mg/mL
Ethanol: 5 mg/mL (18.4 mM)
Solubility (In vivo)
Synonyms
NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol
other peoduct :
| In Vitro |
In vitro activity: Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. Naringenin is the predominant flavanone in grapefruit. This substance has also been shown to reduce oxidative damage to DNA in vitro. Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2, which can change pharmacokinetics in a human (or orthologous) host of several popular agents in an adverse manner, even resulting in carcinogens of otherwise harmless substances. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Intragastrically administered Naringenin (50 mg/kg) induces a significant decrease in plasma glucose in normoglycaemic and non-insulin-dependent diabetes mellitus (NIDDM) rat models. LD50: Mice >5g/kg; Rats >5g/kg. |
| Animal model | |
| Formulation & Dosage | |
| References | Carcinogenesis. 1990 Dec;11(12):2275-9; Diabetes Obes Metab. 2008 Nov;10(11):1097-104. |
