product name NSC59984
Description: NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation. It is a promising lead compound for anti-cancer therapy that targets GOF mutant p53 and stimulates p73 to restore the p53 signaling pathway. The p53 is a tumour-suppressor protein which exerts antiproliferative effects, including growth arrestand apoptosis. In vitro: In SW480 and DLD-1 cells, NSC59984 treatment for 3 hours dose-dependently increased the mRNA levels of p21, Noxa and Puma. NSC59984 was also found to increase p53-responsive reporter activity in both SW480 in a dose-dependent manner.
Reference: [1] Zhang S, et al. Cancer Res. 2015, 75(18), 3842-3852.
