product name Micafungin Sodium
Description: Micafungin Sodium (also known as FK463 Sodium) is an inhibitor of 1, 3-beta-D-glucan synthesis, which is used as an antifungal drug. Micafungin is an antifungal agent known to inhibit 1,3-β-D-glucan synthesis in Candida albicans. In 13 out of 18 P. Aeruginosa isolates tested, micafungin significantly reduced biofilm biomass. In all 9 P. Aeruginosa isolates tested, micafungin decreased the expression of ndvB, which encoded the cell wall 1,3-β-D-glucan. Also, it decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively).
References: Biofouling. 2013 Sep;29(8):909-15; J Antibiot (Tokyo). 2013 Aug;66(8):479-84.
1292.26
Formula
C56H70N9NaO23S
CAS No.
208538-73-2
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 100 mg/mL (77.4 mM)
Water: 100 mg/mL (77.4 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
FK463 Sodium
other peoduct :
| In Vitro |
In vitro activity: Micafungin is an antifungal agent known to inhibit 1,3-β-D-glucan synthesis in Candida albicans. In 13 out of 18 P. Aeruginosa isolates tested, micafungin significantly reduced biofilm biomass. In all 9 P. Aeruginosa isolates tested, micafungin decreased the expression of ndvB, which encoded the cell wall 1,3-β-D-glucan. Also, it decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively). Fungus experiment: Micafungin decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively). Cell Assay: |
|---|---|
| In Vivo | In a mouse model of septic A. fumigatus infection, micafungin (0.1 mg/kg) increased the survival rate of mice to 20%. When micafungin (0.1 mg/kg) combination with KB425796-C (32 mg/kg), the survival rate of mice increased to 100% in the 31-day post-infection period. While non-treated mice survived for only 6 days. |
| Animal model | A mouse model with septic Aspergillus fumigatus (A. fumigatus) infection |
| Formulation & Dosage | 0.1, 0.32 and 1 mg/kg; s.c.; q.d. |
| References | Biofouling. 2013 Sep;29(8):909-15; J Antibiot (Tokyo). 2013 Aug;66(8):479-84. |
