product name Mechlorethamine HCl
Description: Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication. Mechlorethamine is much less toxic to rat hepatocytes under nitrogen and causes much less lipid peroxidation than under aerobic conditions. Mechlorethamine markedly inhibits cell growth and leads to cell detachment associated with rearrangement of the cytoskeletal proteins in rabbit tracheal primary cultures.
References: Toxicol In Vitro. 1997 Oct;11(5):695-702; Cancer Chemother Pharmacol. 1988;22(4):299-302.
192.51
Formula
C5H11Cl2N.HCl
CAS No.
55-86-7
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 39 mg/mL (202.6 mM)
Water: 39 mg/mL (202.6 mM)
Ethanol: 39 mg/mL (202.6 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19412112
| In Vitro |
In vitro activity: Mechlorethamine is much less toxic to rat hepatocytes under nitrogen and causes much less lipid peroxidation than under aerobic conditions. Mechlorethamine markedly inhibits cell growth and leads to cell detachment associated with rearrangement of the cytoskeletal proteins in rabbit tracheal primary cultures. Mechlorethamine results in early lipid peroxidation and cellular membrane damage in rabbit tracheal primary cultures, this is correlated with a significant increase in the activities of antioxidant enzymes associated with an increase in glutathione content Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Mechlorethamine (1.5 mg/kg i.v.) reduces mean leukocyte count from 6,320 mm3 to 1,890 mm3 without any change in the leukocyte differential or erythrocyte and platelet counts in rabbits. Mechlorethamine (0.005 mg-0.5 mg, i.d.) causes dose-dependent skin ulcers in the mouse, and isotonic sodium thiosulfate (0.167 M) or hypertonic (0.34 M) (0.05 mL) given immediately after Mechlorethamine significantly reduces the mean HN2 ulceration area and the total time of ulceration. |
| Animal model | |
| Formulation & Dosage | |
| References | Toxicol In Vitro. 1997 Oct;11(5):695-702; Cancer Chemother Pharmacol. 1988;22(4):299-302. |
