product name ML347
Description: ML347, also known as LDN193719, is a potent and selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. ML347 is discovered as a selective inhibitor of BMP type-I receptor ALK2 versus ALK3 and is identified as a probe molecule. In the in vitro kinase assay, ML347 shows potent inhibitory activities against ALK1 and ALK2 with IC50 values of 46 and 32 nM, respectively. The IC50 value of it for ALK3 is more than 10μM, demonstrating that ML347 is 300-fold more potent against ALK2. Besides that, ML347 exerts no inhibition effect on other related kinases such as ALK6 and KDR.
References: Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.
352.39
Formula
C22H16N4O
CAS No.
1062368-49-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 10 mg/mL (28.4 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
LDN-193719
other peoduct :
| In Vitro |
In vitro activity: ML347 also shows potency in BMP-responsive C2C12BRA cells with IC50 of 15 nM, and designated an MLPCN probe. ML347 displays high plasma protein binding in human, rat and mouse plasma. Kinase Assay: Cell Assay: ML347 also shows effective inhibition with IC50 value of 152nM in the BMP4 cell based assay using C2C12BRA cells. |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52 |
