product name ML324
Description: ML324, also known as CID-44143209, is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM. ML324 displays excellent cell permeability providing an opportunity for more extensive cell-based studies of JMJD2 enzymes to be undertaken. In addition, ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression.
References: Probe Reports from the NIH Molecular Libraries Program; Neuropsychopharmacology. 2016 Oct 26. doi: 10.1038/npp.2016.231.
349.43
Formula
C21H23N3O2
CAS No.
1222800-79-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 43 mg/mL (123.0 mM)
Water: <1 mg/mL
Ethanol: 3 mg/mL (8.6 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19428492
| In Vitro |
In vitro activity: ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression. Kinase Assay: ML324 is a potent and cell-permeable JMJD2 demethylase inhibitor (IC50 = 920 nM). Cell Assay: ML324 acted as an antiviral agent that effectively inhibited HSV and hCMV IE gene expression in HFF and MRC-5 cells, resulted in suppression of HSV plaques formation and inhibition of HSV infection spread. |
|---|---|
| In Vivo | In a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation |
| Animal model | |
| Formulation & Dosage | |
| References | Probe Reports from the NIH Molecular Libraries Program; |
