product name ML167
Description: ML167 (also known as CID 44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. ML167 is found as the first fully selective inhibitor of Clk4 but not other related kinases including Clk1, Clk2 and Clk3 and Dyrk1A/1B. It is 10-fold more potent against Clk4 over other kinases. The treatment of ML167 on Caco-2 cells proves that ML167 is highly cell-permeable. Besides that, ML167 is also found to be an ATP-competitive inhibitor
References: Rosenthal A S, Tanega C, Shen M, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4). 2011.
335.36
Formula
C19H17N3O3
CAS No.
1285702-20-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 67 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: 13 mg/mL (38.8 mM)
Solubility (In vivo)
Synonyms
CID 44968231
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19406119
| In Vitro |
In vitro activity: ML167, as a probe of Clk4, shows high cell permeability in a Caco-2 assay. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Rosenthal A S, Tanega C, Shen M, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4). 2011. |
