product name Levofloxacin
Description: Levofloxacin, a synthetic fluoroquinolone, is a broad-spectrum antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Levofloxacin is used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections. Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate activity against anaerobes.
References: Drugs. 1994 Apr;47(4):677-700; Antimicrob Agents Chemother. 1992 Apr;36(4):860-6.
361.37
Formula
C18H20FN3O4
CAS No.
100986-85-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 24 mg/mL (66.4 mM)
Water: 11 mg/mL (30.4 mM)
Ethanol: 9 mg/mL (24.9 mM)
Solubility (In vivo)
Synonyms
Fluoroquinolone
other peoduct :
| In Vitro |
In vitro activity: Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate activity against anaerobes. Levofloxacin is two-fold more active than ciprofloxacin against Streptococcus pneumoniae and 2- to 4-fold more active than ciprofloxacin against Staphylococcus aureus, Xanthomonas maltophilia, and Bacteroides fragilis. Levofloxacin is two- to eightfold more active than ciprofloxacin against coagulase-negative staphylococci and Acinetobacter spp., although these improvements in potency may not be clinically relevant. Levofloxacin inhibits 90% of streptococci when it is used at concentrations of 1 mg/mL to 2 mg/mL. Levofloxacin exhibits twofold greater inhibitory and bactericidal activities than ofloxacin against either extracellular or intracellular tubercle bacilli. Levofloxacin has the least inhibitory effect on osteoblastic cell growth, with a 50% inhibitory concentration of approximately 80 mg/mL at 48 and 72 hours. Levofloxacin results in strong inhibition of calcium deposition, as determined on day 14 by alizarin red staining and biochemical analysis. Levofloxacin inhibits glycosaminoglycan synthesis initially and DNA synthesis and mitochondrial function secondarily at actual arthropathic concentrations in cultured rabbit chondrocytes but that these changes are reversible and not enough to kill the cells. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Levofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achieves higher concentrations in the serum and tissue of mice than does ciprofloxacin. |
| Animal model | |
| Formulation & Dosage | |
| References | Drugs. 1994 Apr;47(4):677-700; Antimicrob Agents Chemother. 1992 Apr;36(4):860-6. |
