product name Isovaleramide
Description: Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases. It is isolated from the most active fraction of Valeriana pavonii. Isovaleramide (300 µM) exhibits a 42% of inhibition of the binding of ³H-FNZ to its sites in the in vitro assay. Isovaleramide showed no effect at concentrations up to 1000 μM in a variety of in vitro neurotransmitter binding or uptake assays, suggesting that its action does not involve a direct receptor-mediated effect at those systems studied.
References: Biomedica. 2010 Apr-Jun;30(2):245-50; Epilepsy Res. 2004 Sep-Oct;61(1-3):1-48.
101.15
Formula
C5H11NO
CAS No.
541-46-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 20 mg/mL (197.7 mM)
Water: <1 mg/mL
Ethanol: 20 mg/mL (197.7 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19410540
| In Vitro |
In vitro activity: Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases. It is isolated from the most active fraction of Valeriana pavonii. Isovaleramide (300 µM) exhibits a 42% of inhibition of the binding of ³H-FNZ to its sites in the in vitro assay. Isovaleramide is without effect at concentrations up to 1000 μM in a variety of in vitro neurotransmitter binding or uptake assays, suggesting that its action does not involve a direct receptor-mediated effect at those systems studied. Isovaleramide (0.15%) induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Isovaleramide (100 mg/Kg, p.o) evidences a 90% index protection against the maximal electroshock seizure in mice (MES). Isovaleramide produces a consistent pattern of signs at relatively high doses in extensive safety studies in rats, rabbits, and dogs. Isovaleramide shows a significantly lower potential for reproductive toxicity than VPA in several reproductive toxicity studies conducted in mice, rats and rabbits. |
| Animal model | |
| Formulation & Dosage | |
| References | Biomedica. 2010 Apr-Jun;30(2):245-50; Epilepsy Res. 2004 Sep-Oct;61(1-3):1-48. |
