product name Indomethacin
Description: Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin is a synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties and is used to reduce fever, pain, stiffness, and swelling. Indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines.
References: Oncogene. 2001 Feb 1;20(5):645-53; Stroke. 2005 Dec;36(12):2718-24; Inflammation. 1993 Dec;17(6):641-62.
357.79
Formula
C19H16ClNO4
CAS No.
53-86-1
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 72 mg/mL (201.2 mM)
Water: <1 mg/mL
Ethanol: 24 mg/mL (67.1 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19406960
| In Vitro |
In vitro activity: Indomethacin inhibits transcription of a beta-catenin/TCF-responsive reporter gene in a dose dependent manner. Indomethacin also downregulates the beta-catenin/TCF transcriptional target cyclin D1. Indomethacin attenuates the transcription of beta-catenin/TCF-responsive genes, by modulating TCF activity without disrupting beta-catenin/TCF complex formation. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Indomethacin increases BrdU+ cells of all lineages and reduces microglial/monocyte activation in rats after focal cerebral ischemia. Indomethacin (7.5 mg/kg, one injection) produces acute injury and inflammation in the distal jejunum and proximal ileum that are maximal at three days and completely resolves within one week. Indomethacin (two daily subcutaneous injections) produces a more extensive and chronic inflammation that lasts in an active form in more than 75% of the rats for at least two weeks. Indomethacin (4ppm) reduces tumor yield by 78% in SKH:HR-1-hrBr hairless mice. Indomethacin (20 mg/kg, orally) increases the total area of gastric erosions and concentration of lipid peroxides in the gastric mucosa of rats. Indomethacin increases the alpha-tocopherol:total cholesterol ratio in serum. Indomethacin inhibits the increases in gastric mucosal erosions and lipid peroxides in the gastric mucosa, and the reduction of serum alpha-tocopherol. |
| Animal model | |
| Formulation & Dosage | |
| References | Oncogene. 2001 Feb 1;20(5):645-53; Stroke. 2005 Dec;36(12):2718-24; Inflammation. 1993 Dec;17(6):641-62. |
