product name Imidapril HCl
Description: Imidapril HCl is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, it is used as an antihypertensive drug and for the treatment of chronic heart failure. As a prodrug, imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
References: J Cardiovasc Pharmacol. 2014 Jun;63(6):528-32.
441.91
Formula
C20H27N3O6.HCl
CAS No.
89396-94-1
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 88 mg/mL (199.1 mM)
Water: 54 mg/mL (122.19 mM)
Ethanol: 29 mg/mL (65.6 mM)
Solubility (In vivo)
Synonyms
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