product name Ibutilide Fumarate
Description: Ibutilide Fumarate (also known as U-70226E) belongs to the Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. Ibutilide Fumarate is a sodium channel protein inhibitor and methanesulfonanilide anti-arrhythmic agent that prolongs myocardial action potential duration mostly by activation of slow inward sodium current.
References: Chin Med J (Engl). 2012 Aug;125(15):2701-7.
885.23
Formula
(C20H36N2O3S)2.C4H4O4
CAS No.
122647-32-9
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 89 mg/mL (100.5 mM)
Water: 89 mg/mL (100.5 mM)
Ethanol: 89 mg/mL (100.5 mM)
Solubility (In vivo)
Synonyms
U-70226E
other peoduct :
| In Vitro |
In vitro activity: Ibutilide protected against H2O2-induced cardiomyocytes injury through inhibiting endoplasmic reticulum and mitochondrial stress pathways. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Ibutilide significantly decreased defibrillation threshold through the reduction of activation pattern complexity during ventricular fibrillation in canine hearts. |
| Animal model | |
| Formulation & Dosage | |
| References | Chin Med J (Engl). 125, 2701-2707. |
