product name Glycyrrhizic Acid
Description: Glycyrrhizic Acid (also known as Glycyrrhizin) is a widely used anti-inflammatory agent isolated from the licorice root. Glycyrrhizic acid is the chief sweet-tasting constituent of Glycyrrhiza glabra (liquorice) root. Structurally it is a saponin and has been used as an emulsifier and gel-forming agent in foodstuff and cosmetics. Its aglycone is enoxolone and it has therefore been used as a prodrug for that compound, for example it is used in Japan to prevent liver carcinogenesis in patients with chronic hepatitis C.
References: J Steroid Biochem Mol Biol. 2002 Apr;80(4-5):441-7.
822.93
Formula
C42H62O16
CAS No.
1405-86-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 117 mg/mL (142.25 mM)
Water: <1 mg/mL
Ethanol: 165 mg/mL (201.0 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19410543
| In Vitro |
In vitro activity: Licorice-derivatives such as glycyrrhizic acid (GA) competitively inhibit 11 beta-hydroxysteroid dehydrogenase(11 beta-HSD) type 2 (11-HSD2) enzymatic activity, and chronic clinical use often results in pseudoaldosteronism. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Male Wistar rats were given 30, 60 or 120 mg/kg of GA twice a day for 2 weeks. Plasma corticosterone was decreased in those given the 120 mg dose, while urinary corticosterone excretion was increased in those given the 30 and 60 mg doses but decreased in those given 120 mg GA. NAD(+)-dependent dehydrogenase activity in kidney microsomal fraction was decreased in animals receiving doses of 60 and 120 mg GA. The 11-HSD2 protein and mRNA levels were decreased in those given 120 mg GA. In contrast, in vitro studies using mouse kidney M1 cells revealed that 24h treatment with glycyrrhetinic acid did not affect the 11-HSD2 mRNA expression levels. Thus, in addition to its role as a competitive inhibitor of 11-HSD2, the chronic high dose of GA suppresses mRNA and protein expression of 11-HSD2 possibly via indirect mechanisms. These effects may explain the prolonged symptoms after cessation of GA administration in some pseudoaldosteronism patients. |
| Animal model | Male Wistar rats |
| Formulation & Dosage | 30, 60 or 120 mg/kg |
| References | J Steroid Biochem Mol Biol. 2002 Apr;80(4-5):441-7. |
