product name Gabexate Mesylate
Description: Gabexate Mesylate is a potent inhibitor of serine protease with IC50 of 0.19 μM which is used for the treatment of pancreatitis and disseminated intravascular coagulation. Gabexate mesylate binds to the primary specificity site S1 of human and bovine tryptases. The carbonyl group of gabexate mesylate interacts with the oxyanion binding hole of the enzyme. The tighter binding of gabexate mesylate to human tryptase results in a higher affinity than to bovine tryptase.
References: Biochem Biophys Res Commun. 1998 May 19;246(2):453-6.
417.48
Formula
C16H23N3O4.CH4O3S
CAS No.
56974-61-9
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 83 mg/mL (198.8 mM)
Water: 12 mg/mL (28.7 mM)
Ethanol: 83 mg/mL (198.8 mM)
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: Gabexate mesylate is also found to inhibit cNOS and iNOS, with Ki values of 150μM and 5mM. It up-regulates iNOS gene expression. In addition, gabexate mesylate inhibits the LPS/IFNγ-induced NO production with EC50 value of 250μM Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Biochem Biophys Res Commun. 1998 May 19;246(2):453-6. |
