product name Fluocinolone Acetonide
Description: Fluocinolone Acetonide is a synthetic glucocorticoid which acts as an inhibitor of tumor cells. Studies indicate that Fluocinolone Acetonide can inhibit promotion of tumor cells at an early stage of promotion if combined with a promoting agent. In addition, studies suggest that Fluocinolone Acetonide can regulate lipid metabolism by modulating gene expression. Alternate studies show that Fluocinolone Acetonide can inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity.
References: J Oral Pathol Med. 2006 Mar;35(3):161-6; BMC Med Genomics. 2009 Sep 10;2:58. doi: 10.1186/1755-8794-2-58.
452.49
Formula
C24H30F2O6
CAS No.
67-73-2
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 90 mg/mL (198.89 mM)
Water: <1 mg/mL
Ethanol: 12 mg/mL (26.51 mM)
Solubility (In vivo)
Synonyms
Flucort-N
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19422987
| In Vitro |
In vitro activity: Fluocinolone Acetonide is a synthetic glucocorticoid which acts as an inhibitor of tumor cells. Studies indicate that Fluocinolone Acetonide can inhibit promotion of tumor cells at an early stage of promotion if combined with a promoting agent. In addition, studies suggest that Fluocinolone Acetonide can regulate lipid metabolism by modulating gene expression. Alternate studies show that Fluocinolone Acetonide can inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity. Furthermore, Fluocinolone Acetonide can inhibit TNF-α angiogenesis. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | J Oral Pathol Med. 2006 Mar;35(3):161-6; BMC Med Genomics. 2009 Sep 10;2:58. doi: 10.1186/1755-8794-2-58. |
