product name Felbamate
Description: Felbamate (also known as ADD-03055) is an anti-epileptic drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy. Felbamate has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit.
References: Mol Pharmacol. 2004 Feb;65(2):370-80; Epilepsy Res. 2000 Mar;39(1):47-55.
238.24
Formula
C11H14N2O4
CAS No.
25451-15-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 48 mg/mL (201.5 mM)
Water: <1 mg/mL
Ethanol: 3 mg/mL (12.59 mM)
Solubility (In vivo)
Synonyms
ADD-03055
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