product name FPH2 (BRD-9424)
Description: FPH2 (also known as BRD-9424) is a small molecule, which promotes differentiation of iPS-derived hepatocytes. In vitro, FPH2 induced functional proliferation of hepatocytes and might be useful for expanding mature human primary hepatocytes. In human primary hepatocytes, FPH2 increased the number of nuclei undergoing mitosis and hepatocyte nuclei count in a concentration dependent way. Also, FPH2 (40 μM) increased the area of hepatocyte colonies with more hepatocytes and Ki67-positive nuclei, which exhibited hepatocyte nuclear morphologies. In primary human hepatocytes from six additional cell sources, FPH2 increased hepatocytes expansion. FPH2 increased hepatocyte at a rate that is consistent with liver regeneration kinetics in vivo.
References: Nat Chem Biol. 2013 Aug;9(8):514-20.
353.83
Formula
C14H16ClN5O2S
CAS No.
957485-64-2
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 70 mg/mL (197.8 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: FPH2 induces functional proliferation of hepatocytes in vitro, and thus expands mature human primary hepatocytes. FPH2 may lead to the development of new therapeutics for liver diseases. Kinase Assay: Cell Assay: FPH2 (BRD-9424) is an inducer of proliferation of primary human hepatocytes. In vitro, FPH2 induced functional proliferation of hepatocytes and might be useful for expanding mature human primary hepatocytes. In human primary hepatocytes, FPH2 increased the number of nuclei undergoing mitosis and hepatocyte nuclei count in a concentration dependent way. Also, FPH2 (40 μM) increased the area of hepatocyte colonies with more hepatocytes and Ki67-positive nuclei, which exhibited hepatocyte nuclear morphologies. In primary human hepatocytes from six additional cell sources, FPH2 increased hepatocytes expansion. |
|---|---|
| In Vivo | FPH2 increased hepatocyte at a rate that is consistent with liver regeneration kinetics in vivo |
| Animal model | |
| Formulation & Dosage | |
| References | Nat Chem Biol. 2013 Aug;9(8):514-20. |
