product name FH1(BRD-K4477)
Description: FH1 (also known as NSC 12407, BRD-K4477) is a small molecule, which promotes differentiation of iPS-derived hepatocytes. FH1 belongs to the function-only hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. Besides that, FH1 can promote differentiation of iPS-derived hepatocytes towards a more mature phenotype. It doubles albumin secretion during the differentiation of iPS cells into iHeps.
References: Nat Chem Biol. 2013 Aug;9(8):514-20.
282.34
Formula
C17H18N2O2
CAS No.
2719-05-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 56 mg/mL (198.3 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
NSC 12407
other peoduct :
| In Vitro |
In vitro activity: In vitro, FH1(BRD-K4477) enhances hepatocyte functions, and promotes the maturation of well-differentiated cultures of iHeps, which potentially alleviates a major obstacle to the use of iPS cells as a renewable source of functional human hepatocytes. Kinase Assay: Cell Assay: FH1 can promote differentiation of iPS-derived hepatocytes towards a more mature phenotype. It doubles albumin secretion during the differentiation of iPS cells into iHeps. Cultures treated with FH1 contain larger colonies of iHeps were with more pronounced hepatocyte morphologies. Moreover, treatment of FH1 also resulted in the increase of CYP3A4 levels and the decrease of AFP secretion . |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Nat Chem Biol. 2013 Aug;9(8):514-20. |
