product name Clomifene citrate
Description: Clomifene Citrate (also known as NSC 35770) is a selective estrogen receptor modulator used in the treatment of ovulation induction. It acts by inhibiting the action of estrogen on the pituitary. Clomiphene Citrate is an activator of PKC. Clomifene competes with [3H]-QNB and [3H]-nitrendipine for their binding to the receptor in the membrane fractions from the urinary bladder and myometrium. Clomifene inhibits estrogen receptors in the hypothalamus, inhibiting negative feedback of estrogen on gonadotropinrelease.
References: Cancer Chemother Pharmacol. 1990;26(4):310-2; Dongwuxue Yanjiu. 2013 Oct;34(5):487-92.
598.08
Formula
C26H28ClNO.C6H8O7
CAS No.
50-41-9
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 120 mg/mL (200.6 mM)
Water: <1 mg/mL
Ethanol: 11 mg/mL (18.4 mM)
Solubility (In vivo)
Synonyms
NSC 35770
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19418056
| In Vitro |
In vitro activity: Clomifene competes with [3H]-QNB and [3H]-nitrendipine for their binding to the receptor in the membrane fractions from the urinary bladder and myometrium. Clomifene inhibits estrogen receptors in the hypothalamus, inhibiting negative feedback of estrogen on gonadotropinrelease, leading to up-regulation of the hypothalamic–pituitary–gonadal axis. Clomifene is a mixture of two geometric isomers, enclomifene (E-clomifene) and zuclomifene (Z-clomifene). Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Clomiphene citrate treatment significantly increases the chance of homosexuality and effeminized behavior in male mice. |
| Animal model | |
| Formulation & Dosage | |
| References | Cancer Chemother Pharmacol. 1990;26(4):310-2; Dongwuxue Yanjiu. 2013 Oct;34(5):487-92. |
