product name Chrysophanic Acid
Description: Chrysophanic acid (also called Chrysophanol), a natural anthraquinone isolated from Dianella longifolia, is a EGFR/mTOR pathway inhibitor. Chrysophanic acid has anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. It preferentially blocked proliferation of SNU-C5 cells but not in other cell lines with low levels of EGFR expression.
References: Phytother Res. 2011 Jun;25(6):833-7; Antiviral Res. 2001 Mar;49(3):169-78.
254.24
Formula
C15H10O4
CAS No.
481-74-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 5 mg/mL (19.66 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
Chrysophanol
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19416945
| In Vitro |
In Vitro activity: Chrysophanic acid (Chrysophanol) is a EGFR/mTOR pathway inhibitor. Chrysophanic acid (Chrysophanol) is a natural anthraquinone, has anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid (Chrysophanol) preferentially blocks proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid (Chrysophanol) treatment in SNU-C5 cells inhibits EGF-induced phosphorylation of EGFR and suppresses activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid also inhibits the replication of poliovirus types 2 and 3 (Picornaviridae) and poliovirus-induced cytopathic effects in BGM (Buffalo green monkey) kidney cells. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Phytother Res. 2011 Jun;25(6):833-7; Antiviral Res. 2001 Mar;49(3):169-78. |
