product name Cetirizine DiHCl
Description: Cetirizine 2HCl, also known as AC-170, is a second-generation antihistamine and a major metabolite of hydroxyzine. It is a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticarial etc. Second-generation antihistamines like cetirizine are less able to cross the blood-brain barrier and therefore have diminished effects on the central nervous system compared to first-generation drugs, for instance they are less likely to induce drowsiness or to interfere with memory formation.
References: Pharmacology. 2013;92(1-2):14-25; Allergy Proc. 1991 May-Jun;12(3):187-91.
461.81
Formula
C21H25ClN2O3.2HCl
CAS No.
83881-52-1
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 92 mg/mL (199.2 mM)
Water: 92 mg/mL (199.2 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
UCB P071
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19427040
| In Vitro |
In vitro activity: Cetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients with atopic dermatitis. The levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Pharmacology. 2013;92(1-2):14-25; Allergy Proc. 1991 May-Jun;12(3):187-91. |
