product name Calcitriol
Description: Calcitriol (also known as RO215535, Topitriol) is the hormonally active form of vitamin D. Calcitriol is converted to metabolites more potent and rapidly acting than other forms of Vitamin D. Calcitriol has played an important role in mineral and skeletal homeostasis by regulating the differentiation, growth and the function of the cell immune system. In vitro studies, Calcitriol has been reported to dose-dependently inhibit the production of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in human peripheral blood cells (PBMC) stimulated by LPS.
References: J Clin Invest. 1984 Oct;74(4):1451-5; J Biol Chem. 1997 May 2;272(18):11902-7.
416.64
Formula
C27H44O3
CAS No.
32222-06-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 83 mg/mL (199.2 mM)
Water: <1 mg/mL
Ethanol: 83 mg/mL (199.2 mM)
Solubility (In vivo)
Synonyms
RO215535, Topitriol
other peoduct :
| In Vitro |
In vitro activity: Calcitriol is a potent inhibitor of PHA-induced lymphocyte proliferation, achieving 70% inhibition of tritiated thymidine incorporation after 72 h in culture. Calcitriol suppresses interleukin-2 (IL-2) production by PHA-stimulated peripheral blood mononuclear cells in a concentration-dependent fashion. Calcitriol increases the concentration of intracellular calcium ([Ca2+]i) within 5 s by mobilizing calcium from the endoplasmic reticulum and the formation of inositol 1,4, 5-trisphosphate and diacylglycerol. Calcitriol can inhibit the proliferation and promote the differentiation of human prostate adenocarcinoma cells. Calcitriol causes a selective decrease in the secreted levels of type IV collagenases (MMP-2 and MMP-9). Calcitriol has antiproliferative activity in squamous cell carcinoma and prostatic adenocarcinoma and enhances the antitumor activity of platinum-based agents. Calcitriol prior to paclitaxel significantly reduces clonogenic survival compared with either agent alone in the murine squamous cell carcinoma and PC-3 cells. Calcitriol is a potent anti-proliferative agent in a wide variety of malignant cell types. Calcitriol effects are associated with an increase in G0/G1 arrest, induction of apoptosis and differentiation, modulation of expression of growth factor receptors. Calcitriol potentiates the antitumor effects of many cytotoxic agents and inhibits motility and invasiveness of tumor cells and formation of new blood vessels. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | J Clin Invest. 1984 Oct;74(4):1451-5; J Biol Chem. 1997 May 2;272(18):11902-7; Cancer Epidemiol Biomarkers Prev. 1997 Sep;6(9):727-32. |
