product name CK-636
Description: CK-636 (also called CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. CK-636 binds between Arp2 and Arp3 where it appears to block movement of Arp2 and Arp3 into their active conformation and inhibits Arp2/3 complex’s ability to nucleate actin filaments. In a concentration dependence way, CK-636 reduced the formation of actin filament comet tails by Listeria with IC50 value of 22 μM in infected SKOV3 cells.
References: Nature. 2009 Aug 20;460(7258):1031-4; PLoS One. 2013 Sep 12;8(9):e73960.
284.38
Formula
C16H16N2OS
CAS No.
442632-72-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 57 mg/mL (200.4 mM)
Water: <1 mg/mL
Ethanol: 50 mg/mL (175.8 mM)
Solubility (In vivo)
Synonyms
CK-0944636
other peoduct :
| In Vitro |
In vitro activity: CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Nature. 2009 Aug 20;460(7258):1031-4; PLoS One. 2013 Sep 12;8(9):e73960. |
