product name Berberine HCl
Description: Berberine HCl, an isoqinoline alkaloid, is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine has been reported to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis.
References: Metabolism. 2008 May;57(5):712-7; Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Mar;17(3):162-4.
371.81
Formula
C20H18ClNO4
CAS No.
633-65-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: > 10 mM
Water:
Ethanol:
Solubility (In vivo)
Synonyms
Natural Yellow 18; Berberinium chloride; BBR; Umbellatine
other peoduct :
| In Vitro |
In vitro activity: Berberine was found to be able to increase the glucose consumption and/or glucose uptake in the absence of insulin in adipocytes, hepatocytes and myotubes. The enhancing glucose metabolism of berberine might be due to glycolysis stimulation, which was related to the mitochondria oxidation inhibition. Berberine might also act as an alpha-glucosidase inhibitor. In addition, berberine inhibited activities of disaccharidases and decreased glucose transportation cross the intestinal epithelium. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | In diet-induced obese rats, berberine was found to reduce insulin resistance, similar to metformin. Berberin and metformin improved insulin resistance and liver glycogen level in insulin resistance models, but had no effect on insulin, blood glucose, lipid levels and muscle triglyceride depots |
| Animal model | |
| Formulation & Dosage | |
| References | Metabolism.2008 May;57(5):712-7; Zhongguo Zhong Xi Yi Jie He Za Zhi.1997 Mar;17(3):162-4. |
