product name Apoptosis Activator 2
Description: Apoptosis Activator 2 is a small molecule apoptosis activator with IC50 value of about 4μM. Apoptosis Activator 2 is a cell permeable compound that promotes apoptosis by activating caspases in a cytochrome c- and Apaf-1-dependent manner. 20μM Apoptosis Activator 2 increases the fraction of Apaf-1 in the apoptosome when there is 0.15μM cytochrome c. It is found to induce the oligomerization of Apaf-1. Through the induction of apoptosis, Apoptosis Activator 2 notably induces caspase-3 activation, PARP cleavage and DNA fragmentation.
Reference: Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8; Neural Dev. 2009 Mar 16;4:11.
