product name Ammonium Glycyrrhizinate
Description: Ammonium Glycyrrhizinate (also known as AMGZ, Glycyram) potently inhibits growth and cytopathology of several unrelated DNA and RNA viruses. Ammonium glycyrrhizinate (AG) prepared from glycyrrhizin dramatically protects AGS cells from H2O2-induced damage as measured by the integrity of actin cytoskeleton. AG also inhibits FeSO4-induced reactive oxygen radicals in a dose-dependent manner, suggesting the role for AG as a free radical scavenger.
References: Exp Biol Med. 2009;234(3):263-77; Eksp Klin Farmakol. 1997;60(2):65-7; Int J Nanomedicine. 2014;9:635-51.
839.96
Formula
C42H62O16.NH3
CAS No.
1407-03-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 168 mg/mL (200.0 mM)
Water: 5 mg/mL (5.95 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
AMGZ, Glycyram
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19410487
| In Vitro |
In vitro activity: Ammonium glycyrrhizinate (AG) prepared from glycyrrhizin dramatically protects AGS cells from H(2)O(2)-induced damage as measured by the integrity of actin cytoskeleton. AG also inhibits FeSO(4)-induced reactive oxygen radicals in a dose-dependent manner, suggesting the role for AG as a free radical scavenger. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Ammonium glycyrrhizinate (28 mg/kg) leads to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration in mice and rats model. Ammonium glycyrrhizinate-loaded nonionic surfactant vesicles (NSVs) decreases edema and nociceptive responses when compared with Ammonium glycyrrhizinate alone and empty NSVs in mice model. Ammonium glycyrrhizinate up-regulates interleukin-10 (IL-10) level and down-regulates the tumor neurosis factor-α (TNF-α) level and inhibits the cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) activity in the lung tissue of mice. Ammonium glycyrrhizinate -loaded non-ionic surfactant vesicles shows no toxicity, good skin tolerability and are able to improve the drug anti-inflammatory activity in mice. Ammonium glycyrrhizinate significantly decreases triglyceride, cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels in rats. Ammonium glycyrrhizinate increases high density lipoprotein (HDL) levels increased in rats. |
| Animal model | |
| Formulation & Dosage | |
| References | Exp Biol Med (Maywood). 2009 Mar;234(3):263-77; Eksp Klin Farmakol. 1997 Mar-Apr;60(2):65-7; Int J Nanomedicine. 2014 Jan 24;9:635-51. |
