product name Amlodipine Besylate
Description: Amlodipine (also known as UK-48340 and used as as besylate, mesylate or maleate) is a long-acting calcium channel blocker that belongs to the dihydropyridine class. It is a medication used to lower blood pressure and prevent chest pain. Amlodipine causes a dose-dependent increase in nitrite production. Amlodipine also increases nitrite production in large coronary arteries and in aorta. Amlodipine is attributed to distinct membrane physico-chemical interactions.
References: J Mol Cell Cardiol. 1999 Jan;31(1):275-81; J Hypertens. 1998 Apr;16(4):457-66.
567.05
Formula
C20H25ClN2O5.C6H6O3S
CAS No.
111470-99-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 113 mg/mL (199.3 mM)
Water: < 1 mg/mL
Ethanol: 14 mg/mL (24.7 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19403470
| In Vitro |
In vitro activity: Amlodipine causes a dose-dependent increase in nitrite production. Amlodipine also increases nitrite production in large coronary arteries and in aorta. Amlodipine is attributed to distinct membrane physico-chemical interactions. Amlodipine contributes to distinct membrane biophysical interactions that lead to potent lipid antioxidant effects, independent of calcium channel modulation. Amlodipine increases plaque smooth muscle cell content (P<0.05), whereas atenolol decreases plaque inflammation. Amlodipine attenuates intracellular neuronal Ca2+ increases elicited by KCl depolarization but does not affect Ca2+ changes triggered by N-methyl-D-aspartate receptor activation. Amlodipine also inhibits free radical-induced damage to lipid constituents of the membrane in a dose-dependent manner, independent of Ca2+ channel modulation Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Amlodipine results in regression of cardiovascular hypertrophy and amelioration of endothelial dysfunction in spontaneously hypertensive rats. Amlodipine significantly reduces aortic hypertrophy, endothelial dysfunction, LOX-1 expression, aortic O(2)(-) and ONOO(-) production, and plasma free 8-F(2)alpha-isoprostane levels in Ang II-infused rats. Amlodipine has antihypertensive and antioxidant activity in vivo, which effectively inhibits many of the oxidative stress-dependent mechanisms involved in Ang II-mediated cardiovascular injury. |
| Animal model | |
| Formulation & Dosage | |
| References | J Mol Cell Cardiol. 1999 Jan;31(1):275-81; J Hypertens. 1998 Apr;16(4):457-66 |
Related Posts
product name Amlodipine Besylate
Description: Amlodipine (also known as UK-48340 and used as as besylate, mesylate or maleate) is a long-acting calcium channel blocker that belongs to the dihydropyridine class. It is a medication used to lower blood pressure and prevent chest pain. Amlodipine causes a dose-dependent increase in nitrite production. Amlodipine also increases nitrite production in large coronary arteries and in aorta. Amlodipine is attributed to distinct membrane physico-chemical interactions.
References: J Mol Cell Cardiol. 1999 Jan;31(1):275-81; J Hypertens. 1998 Apr;16(4):457-66.
567.05
Formula
C20H25ClN2O5.C6H6O3S
CAS No.
111470-99-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 113 mg/mL (199.3 mM)
Water: < 1 mg/mL
Ethanol: 14 mg/mL (24.7 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19403470
| In Vitro |
In vitro activity: Amlodipine causes a dose-dependent increase in nitrite production. Amlodipine also increases nitrite production in large coronary arteries and in aorta. Amlodipine is attributed to distinct membrane physico-chemical interactions. Amlodipine contributes to distinct membrane biophysical interactions that lead to potent lipid antioxidant effects, independent of calcium channel modulation. Amlodipine increases plaque smooth muscle cell content (P<0.05), whereas atenolol decreases plaque inflammation. Amlodipine attenuates intracellular neuronal Ca2+ increases elicited by KCl depolarization but does not affect Ca2+ changes triggered by N-methyl-D-aspartate receptor activation. Amlodipine also inhibits free radical-induced damage to lipid constituents of the membrane in a dose-dependent manner, independent of Ca2+ channel modulation Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Amlodipine results in regression of cardiovascular hypertrophy and amelioration of endothelial dysfunction in spontaneously hypertensive rats. Amlodipine significantly reduces aortic hypertrophy, endothelial dysfunction, LOX-1 expression, aortic O(2)(-) and ONOO(-) production, and plasma free 8-F(2)alpha-isoprostane levels in Ang II-infused rats. Amlodipine has antihypertensive and antioxidant activity in vivo, which effectively inhibits many of the oxidative stress-dependent mechanisms involved in Ang II-mediated cardiovascular injury. |
| Animal model | |
| Formulation & Dosage | |
| References | J Mol Cell Cardiol. 1999 Jan;31(1):275-81; J Hypertens. 1998 Apr;16(4):457-66 |