product name Alprostadil
Description: Alprostadil (also known as Prostaglandin-E1) is a naturally occurring prostaglandin used in the treatment of infants with congenital heart defects to maintain the patency of the ductus arteriosus until palliative or corrective surgery can be performed. In infants with defects restricting pulmonary blood flow (cyanotic), alprostadil improves arterial blood oxygenation. In infants with defects restricting systemic blood flow, alprostadil improves arterial blood pH, urine output, and femoral arterial pulses. Alprostadil is administered by continuous intraarterial or intravenous infusion, usually at a starting dose of 0.1 microgram/kg/min, with maintenance doses as low as 0.002 microgram/kg/min.
References: Br J Clin Pharmacol. 1995 Sep;40(3):273-6; Drug Intell Clin Pharm. 1982 Nov;16(11):823-32; Int J Impot Res. 2002 Dec;14(6):498-501.
354.48
Formula
C20H34O5
CAS No.
745-65-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 71 mg/mL (200.3 mM)
Water: <1 mg/mL
Ethanol: 71 mg/mL (200.3 mM)
Solubility (In vivo)
Synonyms
Prostaglandin-E1
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