product name Adrenalone HCl
Description: Adrenalone is a potent adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors. Adrenalone (12 μM) inhibits conversion of dopamine to norepinephrine by inhibiting dopamine β oxidase. The structure of Adrenalone differs from epinine only in that the former possesses a ketone group in the β position. The reduction of adrenalone (0.1 mM) by hydrated electrons in nitrogenated aqueous solutions containing either 10 or 100 mM tert-butyl alcohol results in identical transient spectra, therefore all OH radicals have been scavenged.
References: Nature. 1961 Dec 16;192:1081; Exp Eye Res. 1984 Jun;38(6):621-6.
217.65
Formula
C9H11NO3.HCl
CAS No.
62-13-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 44 mg/mL (202.2 mM)
Water: 44 mg/mL (202.2 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19398706
| In Vitro |
In vitro activity: Adrenalone (12 μM) inhibits conversion of dopamine to norepinephrine by inhibiting dopamine β oxidase. The structure of Adrenalone differs from epinine only in that the former possesses a ketone group in the β position. The reduction of adrenalone (0.1 mM) by hydrated electrons in nitrogenated aqueous solutions containing either 10 or 100 mM tert-butyl alcohol results in identical transient spectra, therefore all OH radicals have been scavenged. While adrenalone behaves like a carbonyl compound during reduction, oxidation reactions are primarily governed by the catechol functional group. Adrenalone, which is a topical nasal decongestant, hemostatic, and vasoconstrictor, is a keton form of the natural substrate epinephrine. Adrenalone contains an aromatic ring that forms hydrophobic interactions with Phe72, Tyr152, and Phe317, an amine group that forms an ionic bond with Asp75, and a hydroxyl group that forms a hydrogen bond with Ala145. Adrenalone at 10 μM (100 μM) reduces substrate uptake to 99% (27%). Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Adrenalone (0.05%) administrated topically to the eyes of rabbits at 30 min intervals results in concentration of 7.75 mg/kg, 0.87 mg/kg and 2.51 mg/kg in cornea, aqueous humor and iris-ciliary body, respectively. |
| Animal model | |
| Formulation & Dosage | |
| References | Nature. 1961 Dec 16;192:1081; Exp Eye Res. 1984 Jun;38(6):621-6. |
Related Posts
product name Adrenalone HCl
Description: Adrenalone is a potent adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors. Adrenalone (12 μM) inhibits conversion of dopamine to norepinephrine by inhibiting dopamine β oxidase. The structure of Adrenalone differs from epinine only in that the former possesses a ketone group in the β position. The reduction of adrenalone (0.1 mM) by hydrated electrons in nitrogenated aqueous solutions containing either 10 or 100 mM tert-butyl alcohol results in identical transient spectra, therefore all OH radicals have been scavenged.
References: Nature. 1961 Dec 16;192:1081; Exp Eye Res. 1984 Jun;38(6):621-6.
217.65
Formula
C9H11NO3.HCl
CAS No.
62-13-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 44 mg/mL (202.2 mM)
Water: 44 mg/mL (202.2 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19398706
| In Vitro |
In vitro activity: Adrenalone (12 μM) inhibits conversion of dopamine to norepinephrine by inhibiting dopamine β oxidase. The structure of Adrenalone differs from epinine only in that the former possesses a ketone group in the β position. The reduction of adrenalone (0.1 mM) by hydrated electrons in nitrogenated aqueous solutions containing either 10 or 100 mM tert-butyl alcohol results in identical transient spectra, therefore all OH radicals have been scavenged. While adrenalone behaves like a carbonyl compound during reduction, oxidation reactions are primarily governed by the catechol functional group. Adrenalone, which is a topical nasal decongestant, hemostatic, and vasoconstrictor, is a keton form of the natural substrate epinephrine. Adrenalone contains an aromatic ring that forms hydrophobic interactions with Phe72, Tyr152, and Phe317, an amine group that forms an ionic bond with Asp75, and a hydroxyl group that forms a hydrogen bond with Ala145. Adrenalone at 10 μM (100 μM) reduces substrate uptake to 99% (27%). Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Adrenalone (0.05%) administrated topically to the eyes of rabbits at 30 min intervals results in concentration of 7.75 mg/kg, 0.87 mg/kg and 2.51 mg/kg in cornea, aqueous humor and iris-ciliary body, respectively. |
| Animal model | |
| Formulation & Dosage | |
| References | Nature. 1961 Dec 16;192:1081; Exp Eye Res. 1984 Jun;38(6):621-6. |