product name AdipoRon
Description: AdipoRon (also known as SC-396658) is a novel, first-in-class, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively. AdipoRon (5-50 μM) increased AMPK phosphorylation via AdipoR1 in a dose-dependent way. Also, AdipoRon replenished adiponectin-stimulated AMPK phosphorylation. In C2C12 myotubes, AdipoRon increased PGC-1α expression and mitochondrial DNA content in a Ca2+- and dose-dependent way.
References: Nature. 2013 Nov 28;503(7477):493-9.
428.52
Formula
C27H28N2O3
CAS No.
924416-43-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 86 mg/mL (200.7 mM)
Water: <1 mg/mL
Ethanol: 50 mg/mL (116.7 mM)
Solubility (In vivo)
Synonyms
SC-396658
other peoduct :
| In Vitro |
In vitro activity: AdipoRon increases AMPK activation, PGC-1α expression and mitochondrial biogenesis by binding to both AdipoR1 and AdipoR2 in C2C12 myotubes. Kinase Assay: Cell Assay: In C2C12 myotubes, AdipoRon increased PGC-1α expression and mitochondrial DNA content in a Ca2+- and dose-dependent way, |
|---|---|
| In Vivo | In skeletal muscle and liver of wild-type mice AdipoRon (50 mg/kg, i.v.) significantly induces phosphorylation of AMPK via AdipoR1 and AdipoR2. In WT mice, AdipoRon (50 mg/kg, p.o.) improves insulin resistance, glucose intolerance and dyslipidaemia by activating AdipoR1–AMPK–PGC-1α pathways in skeletal muscle, while by activating AdipoR2–PPAR-α pathways in the liver. Moreover, AdipoRon ameliorates diabetes of genetically obese rodent model db/db mice, and prolongs the shortened lifespan of db/db mice on a high-fat diet. |
| Animal model | |
| Formulation & Dosage | |
| References | Nature. 2013 Nov 28;503(7477):493-9. |
