product name 8-Bromo-cAMP
Description: 8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator. 8-Bromo-cAMP increased the cellular content of mRNA encoding the hCG a- and β-subunits and prevented the increase in fibronectin mRNA. This is determined by blot hybridization analysis using specific cDNA probes. 8-Bromo-cAMP also induced phosphorylation of Erk1,2 in AML193 cells. 8-Bromo-cAMP is an agent in AML193 cells and activates Erk1,2 , this condition happens does not accompanied by the involvement of Shc phosphorylation.
References: Stem Cell Rev. 2011 Jun;7(2):331-41; Am J Physiol Lung Cell Mol Physiol. 2014 Oct 15;307(8):L643-51.
430.08
Formula
C10H10BrN5NaO6P
CAS No.
76939-46-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 80 mg/mL (186.01 mM)
Water: < 1 mg/mL
Ethanol: 35 mg/mL (81.38 mM)
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: 8-Bromo-cAMP improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. In bronchial epithelial cells, 8-Bromo-cAMP decreases HDE-stimulated tumor necrosis factor (TNF)-α-converting enzyme (TACE; ADAM-17) activity and subsequent TNF-α release. Kinase Assay: Cell Assay: 8-Bromo-cAMP increased the cellular content of mRNA encoding the hCG a- and β-subunits and prevented the increase in fibronectin mRNA. This is determined by blot hybridization analysis using specific cDNA probes. 8-Bromo-cAMP also induced phosphorylation of Erk1,2 in AML193 cells. 8-Bromo-cAMP is an agent in AML193 cells and activates Erk1,2 , this condition happens does not accompanied by the involvement of Shc phosphorylation. |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Stem Cell Rev. 2011 Jun;7(2):331-41; Am J Physiol Lung Cell Mol Physiol. 2014 Oct 15;307(8):L643-51. |
