product name 4E1RCat
Description: 4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and also inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM. 4E1RCat prevents assembly of the eIF4F complex and inhibits cap-dependent translation. 4E1RCat significantly inhibited 5′-cap-mediated mCherry synthesis while had little effect on the IRES-mediated DIAPH1-HA synthesis, which confirmed the specific inhibitory effect of 4E1RCat on 5′-cap-mediated translation.
References: Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1046-51; PLoS One. 2013 Jun 28;8(6):e68190.
478.45
Formula
C28H18N2O6
CAS No.
328998-25-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 96 mg/mL (200.6 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :
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In vitro activity: Kinase Assay: Cell Assay: |
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| References |
Dorsomorphin (dihydrochloride)
