Tch is always Author Contributions Conceived and designed the experiments: MZ HQ. Performed the experiments: AYY QL CL HQ. Analyzed the 1317923 data: AYY HQ. Wrote the paper: AYY QL MZ HQ. References 1. Nelson DL, I-BRD9 cost Lehninger AL, Cox MM Lehninger principles of biochemistry. New York: W.H. Freeman. 2. Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, et al. Membrane get Salmon calcitonin transporters in drug improvement. Nat Rev Drug Discov 9: 215236. three. Overington JP, Al-Lazikani B, Hopkins AL How lots of drug targets are there Nat Rev Drug Discov five: 993996. four. Rask-Andersen M, Almen MS, Schioth HB Trends within the exploitation of novel drug targets. Nat Rev Drug Discov 10: 579590. five. Ware JA Membrane transporters in drug discovery and development: A new mechanistic ADME era. Mol Pharm 3: 12. six. 11967625 Yan Q Membrane transporters and drug improvement: relevance to pharmacogenomics, nutrigenomics, epigenetics, and systems biology. Solutions Mol Biol 637: 121. 7. Cardoso AR, Queliconi BB, Kowaltowski AJ Mitochondrial ion transport pathways: part in metabolic diseases. Biochim Biophys Acta 1797: 832838. eight. Longo N, Ardon O, Vanzo R, Schwartz E, Pasquali M Problems of creatine transport and metabolism. Am J Med Genet C Semin Med Genet 157: 7278. 9. Ueda K ABC proteins protect the human physique and keep optimal health. Biosci Biotechnol Biochem 75: 401409. ten. van Veen HW Structural biology: Final of the multidrug transporters. Nature 467: 926927. 11. Zhao FQ, Keating AF Functional properties and genomics of glucose transporters. Curr Genomics eight: 113128. 12. Huang Y Pharmacogenetics/genomics of membrane transporters in cancer chemotherapy. Cancer Metastasis Rev 26: 183201. 13. Saier MH Jr, Tran CV, Barabote RD TCDB: the Transporter Classification Database for membrane transport protein analyses and data. Nucleic Acids Res 34: D181186. 14. Ren Q, Chen K, Paulsen IT TransportDB: a extensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Nucleic Acids Res 35: D274279. 7 Human Transporter Gene Database 15. Kanehisa M, Goto S, Furumichi M, Tanabe M, Hirakawa M KEGG for representation and analysis of molecular networks involving illnesses and drugs. Nucleic Acids Res 38: D355360. 16. Yan Q, Sadee W Human membrane transporter database: a Webaccessible relational database for drug transport research and pharmacogenomics. AAPS PharmSci 2: E20. 17. Zhao M, Chen Y, Qu D, Qu H TSdb: a database of transporter substrates linking metabolic pathways and transporter systems on a genome scale by way of their shared substrates. Science China-Life Sciences 54: 6064. 18. Fichant G, Basse MJ, Quentin Y ABCdb: a web based resource for ABC transporter repertories from sequenced archaeal and bacterial genomes. FEMS Microbiol Lett 256: 333339. 19. Miao Z, Li D, Zhang Z, Dong J, Su Z, Wang T Medicago truncatula transporter database: a comprehensive database resource for M. truncatula transporters. BMC Genomics. 13: 60. 20. Hodges LM, Markova SM, Chinn LW, Gow JM, Kroetz DL, et al. Pretty essential pharmacogene summary: ABCB1. Pharmacogenet Genomics 21: 152161. 21. Oshiro C, Mangravite L, Klein T, Altman R PharmGKB quite important pharmacogene: SLCO1B1. Pharmacogenetics and Genomics 20: 211216. 22. Li CY, Yu Q, Ye ZQ, Sun Y, He Q, et al. A nonsynonymous SNP in human cytosolic sialidase inside a compact Asian population benefits in reduced enzyme activity: prospective link with extreme adverse reactions to oseltamivir. Cell Res 17: 357362. 23. Hwang D, Rust AG, Ramsey S, Smith.Tch is generally Author Contributions Conceived and designed the experiments: MZ HQ. Performed the experiments: AYY QL CL HQ. Analyzed the 1317923 data: AYY HQ. Wrote the paper: AYY QL MZ HQ. References 1. Nelson DL, Lehninger AL, Cox MM Lehninger principles of biochemistry. New York: W.H. Freeman. two. Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, et al. Membrane transporters in drug development. Nat Rev Drug Discov 9: 215236. 3. Overington JP, Al-Lazikani B, Hopkins AL How lots of drug targets are there Nat Rev Drug Discov five: 993996. four. Rask-Andersen M, Almen MS, Schioth HB Trends inside the exploitation of novel drug targets. Nat Rev Drug Discov 10: 579590. 5. Ware JA Membrane transporters in drug discovery and improvement: A new mechanistic ADME era. Mol Pharm three: 12. 6. 11967625 Yan Q Membrane transporters and drug improvement: relevance to pharmacogenomics, nutrigenomics, epigenetics, and systems biology. Solutions Mol Biol 637: 121. 7. Cardoso AR, Queliconi BB, Kowaltowski AJ Mitochondrial ion transport pathways: role in metabolic ailments. Biochim Biophys Acta 1797: 832838. eight. Longo N, Ardon O, Vanzo R, Schwartz E, Pasquali M Issues of creatine transport and metabolism. Am J Med Genet C Semin Med Genet 157: 7278. 9. Ueda K ABC proteins protect the human body and sustain optimal health. Biosci Biotechnol Biochem 75: 401409. 10. van Veen HW Structural biology: Final in the multidrug transporters. Nature 467: 926927. 11. Zhao FQ, Keating AF Functional properties and genomics of glucose transporters. Curr Genomics eight: 113128. 12. Huang Y Pharmacogenetics/genomics of membrane transporters in cancer chemotherapy. Cancer Metastasis Rev 26: 183201. 13. Saier MH Jr, Tran CV, Barabote RD TCDB: the Transporter Classification Database for membrane transport protein analyses and information. Nucleic Acids Res 34: D181186. 14. Ren Q, Chen K, Paulsen IT TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Nucleic Acids Res 35: D274279. 7 Human Transporter Gene Database 15. Kanehisa M, Goto S, Furumichi M, Tanabe M, Hirakawa M KEGG for representation and analysis of molecular networks involving illnesses and drugs. Nucleic Acids Res 38: D355360. 16. Yan Q, Sadee W Human membrane transporter database: a Webaccessible relational database for drug transport research and pharmacogenomics. AAPS PharmSci 2: E20. 17. Zhao M, Chen Y, Qu D, Qu H TSdb: a database of transporter substrates linking metabolic pathways and transporter systems on a genome scale by means of their shared substrates. Science China-Life Sciences 54: 6064. 18. Fichant G, Basse MJ, Quentin Y ABCdb: an internet resource for ABC transporter repertories from sequenced archaeal and bacterial genomes. FEMS Microbiol Lett 256: 333339. 19. Miao Z, Li D, Zhang Z, Dong J, Su Z, Wang T Medicago truncatula transporter database: a complete database resource for M. truncatula transporters. BMC Genomics. 13: 60. 20. Hodges LM, Markova SM, Chinn LW, Gow JM, Kroetz DL, et al. Extremely crucial pharmacogene summary: ABCB1. Pharmacogenet Genomics 21: 152161. 21. Oshiro C, Mangravite L, Klein T, Altman R PharmGKB incredibly vital pharmacogene: SLCO1B1. Pharmacogenetics and Genomics 20: 211216. 22. Li CY, Yu Q, Ye ZQ, Sun Y, He Q, et al. A nonsynonymous SNP in human cytosolic sialidase within a little Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. Cell Res 17: 357362. 23. Hwang D, Rust AG, Ramsey S, Smith.
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