Ined by a SOFA score 3.SAvailable online http://ccforum.com/supplements/11/SFigure 1 (abstract P464)*Classified as + if predicted mortality 0.five. Domax, the maximum number of organ failures in the course of ICU stay.SOFA was defined by TMS minus admission SOFA (SOFAi). The maximum SOFA was defined by the worst SOFA value through the ICU keep. Logistic regression modeling strategies had been applied to describe the association of derived SOFA variables and SAPS II with mortality. ROC curves were applied to assess the model’s discriminatory capability and we examined the model calibration working with the Hosmer emeshow goodness-of-fit test. P < 0.05 was considered significant. Results Diagnostic categories were: trauma 21.3 , postoperative 19 and medical 59.7 . Global mortality was 34.3 . Survivors had lower average SAPS II (28.1 ?14 against 48.6 ?19, P < 0.01), SOFAi score (3.7 ?3 against 7.2 ?4, P < 0.01), SOFAmax score (4.6 ?4 against 10.8 ?3, P < 0.01), SOFA (1.6 ?6 against 4.2 ?3, P < 0.01), DoMAX (1.6 ?6 against 4.2 ?3, P < 0.01) and TMS (5 ?3 against 11.4 ?4, P < 0.01), and the difference was statistically significant. Results regarding model calibration and discriminatory ability are presented in Figure 1. Conclusion The SOFAmax score had the best model calibration and could be used to compare different patient populations in terms of mortality.Results One hundred and seventy-six patients were studied (71 males (56 ), median age 51 (IQR 36?7) years, 78 (44 ) with severe sepsis, median length of ICU stay 10 days (IQR 7?6), median admission SOFA 6 (IQR 4?), median APACHE II score 19 (IQR 13?6), ICU mortality 27.84 (49/176 patients)). The SOFA score and its components scores along the five admission days distinguished the survivors from the nonsurvivors. Considering the SOFA score and its respiratory, neurologic and circulatory components, survivors presented lower scores as the days passed (P < 0.001). Mortality was increasingly higher for those patients who persisted with a SOFA score 7 as the days passed. Conclusion In the sample studied, the persistence of an elevated SOFA score and its components during the first 5 days of admission predicted a higher mortality. Survival PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20800409 appears to be related to early organ dysfunction recovery. The SOFA score and SOFA-related variables’ day-to-day changes within a TC-G-1008 population of septic patients might have a crucial prognostic implication and some patterns of everyday evolution may well distinguish these sufferers with a more ominous outcome.P466 Cumulative lactate load correlates with cumulative Sequential Organ Failure Assessment score and survival in intensive care unit patients1GelreP Spronk1, L Brander2, S Jansen1, J Rommes1 Ziekenhuizen Place Lukas, Apeldoorn, The Netherlands; 2University Hospital, Bern, Switzerland Essential Care 2007, 11(Suppl two):P466 (doi: 10.1186/cc5626) Background Alterations in lactate levels are employed as a prognostic marker in critically ill sufferers. Nonetheless, the relation among the time course of arterial blood lactate clearance and vital outcome parameters such as ICU length of keep (LOS), incidence of organ failure and survival rate has not been established. Techniques Case records from all ICU individuals admitted in between 2002 and 2004 had been retrospectively identified in the ICU database. The Sequential Organ Failure Assessment (SOFA) score was calculated each day to assess the time course of organ failure. All lactate levels were extracted along with the total cumulative lactate load (area beneath the curve above the.
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