product name Dibucaine HCl
Description: Dibucaine HCl (also known as Cinchocaine) is one of the most potent and toxic of the long-acting local anesthetics. Dibucaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle. Dibucaine HCl blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membranes permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
References: Biochim Biophys Acta. 1987 May 29;899(2):196-204; Biochim Biophys Acta. 1987 May 29;899(2):196-204.
379.92
Formula
C20H29N3O2.HCl
CAS No.
61-12-1
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 76 mg/mL (200.0 mM)
Water: 76 mg/mL (200.0 mM)
Ethanol: 76 mg/mL (200.0 mM)
Solubility (In vivo)
Synonyms
Cinchocaine HCl
other peoduct :
| In Vitro |
In vitro activity: Dibucaine (Cinchocaine) HCl is one of the most potent and toxic of the long-acting local anesthetics. Dibucaine (Cinchocaine) HCl blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membranes permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Biochim Biophys Acta. 1987 May 29;899(2):196-204; Biochim Biophys Acta. 1987 May 29;899(2):196-204. |
