product name SirReal2
Description: SirReal2 is a highly potent and selective Sirt2 inhibitor with IC50 of 140 nM. The Sirtuins are a highly conserved class of NAD+-dependent lysine deacylases. The human isotype Sirtuin 2 (Sirt2) deacetylates both cytoplasmatic and nuclear proteins and it has been implicated in the pathogenesis of cancer, neurodegeneration, and inflammation. Therefore, the modulation of Sirt2 activity is a promising strategy for pharmaceutical intervention.
References: Nat Commun. 2015 Feb 12;6:6263.
420.55
Formula
C22H20N4OS2
CAS No.
709002-46-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 84 mg/mL (199.7 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: SirReal2 selectively inhibits Sirt2 via a Sirt2-specific amino acid network, and induces a tubulin hyperacetylation and a significant depletion of BubR1 in HeLa cells. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | In vivo, SirReal2 inhibits Sirt2 activity without affecting the activity of the other Class-I sirtuins Sirt1 and Sirt3. |
| Animal model | |
| Formulation & Dosage | SirReal2 (12.5, 25, and 50 μM) treatment did not induce the increase in acetylation of p53 |
| References | Nat Commun. 2015 Feb 12;6:6263 |
