product name Pantoprazole
Description: Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Pantoprazole inhibits the activity of H+/K+-ATPase proton pumb in the parietal cells of gastric mucosa. This inhibition affects the acid secretion and thus, pantoprazole are used as drugs for the treatment of various acid-related disorders. Pantoprazole is activated slowly. The activated sulfonamide of pantoprazole binds to Cys813 and Cys822 of the pumb and inhibits acid secretion selectively.
References: Clin Ther. 2000 Nov;22(11):1268-93.
383.37
Formula
C16H15F2N3O4S
CAS No.
102625-70-7
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 76 mg/mL (198.2 mM)
Water: <1 mg/mL
Ethanol: 76 mg/mL (198.2 mM)
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: Pantoprazole inhibited lysosomal acidification with IC50 value of 194 μM. The pKa values of pantoprazole are 3.83 (pKa1) and 0.11 (pKa2). Besides that, pantoprazole also shows antibacterial effects on Helicobacter pylori. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Clin Ther. 2000 Nov;22(11):1268-93. |
