product name Dibutyryl-cAMP (Bucladesine)
Description: Dibutyryl-cAMP (also known as Bucladesine) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. It is a cyclic nucleotide derivative that mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor. Dibutyryl-cAMP preferentially activates cAMP-dependent protein kinase. The products releaes butyrate due to intracellular and extracellular esterase action. Butyrate was shown to have distinct biological effects. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions.
References: Exp Neurol. 2001 Jan;167(1):59-64.
491.37
Formula
C18H23N5NaO8P
CAS No.
16980-89-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 98 mg/mL (199.4 mM)
Water: 98 mg/mL (199.4 mM)
Ethanol:
Solubility (In vivo)
10% DMSO+ddH2O: 30 mg/mL
Synonyms
dbcAMP
other peoduct :
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In vitro activity: Kinase Assay: Cell Assay: |
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