product name Luteolin
Description: Luteolin is a flavonoid isolated from plants such as Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Luteolin possesses many beneficial properties including antioxidant, anti- inflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions.
References: Eur J Pharmacol. 2010 Feb 10;627(1-3):269-75; J Pharmacol Exp Ther. 2001 Jan;296(1):181-7.
286.24
Formula
C15H10O6
CAS No.
491-70-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 57 mg/mL (199.1 mM)
Water: <1 mg/mL
Ethanol: 3 mg/mL (10.5 mM)
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Eur J Pharmacol. 2010 Feb 10;627(1-3):269-75; J Pharmacol Exp Ther. 2001 Jan;296(1):181-7. |
