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product name NSC 319726


Description: NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells. NSC 319726 is a reactivator of mutant p53 with IC50 value of 8nM. NSC 319726 belongs to the thiosemicarbazone family. In a mouse fibroblast cell line Balb/c 3T3, NSC 319726 shows greater inhibition of cell growth in cells expressing mutant p53 than in WT p53 control. NSC 319726 is also nontoxic to WI38 human fibroblasts (p53 WT).

Reference: Cancer Cell. 2012 May 15;21(5):614-25.



Molecular Weight (MW)

234.32
Formula

C11H14N4S
CAS No.

71555-25-4
Storage

-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)

DMSO: 19 mg/mL (81.08 mM)
Water: <1 mg/mL (slightly soluble or insoluble)
Ethanol:  <1 mg/mL
Solubility (In vivo)

 

other peoduct :

General NSC319726 (5mg/kg, 7days) exhibits greater toxicity for p53(R172H/R172H) mice, with only 30% survival, as compared to 100% survival for p53+/+ and p53-/- mice. NSC319726 inhibits the growth of TOV112D-p53(R175H) xenografts, but not H460 (p53+/+) and MDAMB468-p53(R273W) xenografts.
Animal model p53+/+, p53-/- and p53R172H knockin mice
Formulation DMSO
Dosages 5-10 mg/kg/day, up to 7 days
Administration i.p.
Reference [1] Yu X, et al. Cancer Cell, 2012, 21(5), 614-625.

AR-C155860