product name Pioglitazone HCl
Description: Pioglitazone HCl (also known as AD-4833, U-72107E), is a potent and selective PPARϒ agonist, which is used to treat diabetes. Pioglitazone Hydrochloride is a thiazolidinedione compound described to produce antiinflammatory and antiarteriosclerotic effects. Pioglitazone is demonstrated to prevent L-NAME-induced coronary inflammation and arteriosclerosis and to suppress increased TNF-α mRNA produced by aspirin-induced gastric mucosal injury.
References: J Neuroinflammation. 2008 Jan 18;5:4. doi: 10.1186/1742-2094-5-4; Arzneimittelforschung. 1990 Mar;40(3):263-7; J Neurosci. 2005 Aug 24;25(34):7805-12.
392.9
Formula
C19H20N2O3S.HCl
CAS No.
112529-15-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 79 mg/mL (201.1 mM)
Water: <1 mg/mL
Ethanol: 4 mg/mL (10.2 mM)
Solubility (In vivo)
Synonyms
AD-4833, U-72107E
other peoduct :
| In Vitro |
In vitro activity: Pioglitazone inhibits LPS-induced iNOS expression and NO generation, and inhibition of iNOS is sufficient to protect dopaminergic neurons against LPS insult. Pioglitazone protects dopaminergic neurons against LPS insult at least via inhibiting iNOS expression and NO generation, which is potentially mediated via inhibition of p38 MAPK activity. Pioglitazone inhibits LPS-induced phosphorylation of p38 MAPK. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Pioglitazone administered orally (0.3-3 mg/kg/d for 7 days) dose dependently reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in male fatty rats. Pioglitazone improves glucose tolerance and augmentes the glycemic response to exogenous insulin and clearance of plasma triglyceride in rats. Pioglitazone-treated transgenic mice reveals improved muscle strength and body weight, exhibits a delayed disease onset, and survives significantly longer than nontreated SOD1-G93A mice. Pioglitazone markedly decreases hyperglycemia, hyperlipidemia, hyperinsulinemia, and glucoseintolerance characterized as insulin resistant states in these rats and mice. Pioglitazone potentiates insulin-mediated glucose metabolism in the diaphragm and adipose tissues of yellow KK mice and enhanced the glycemic response to exogenous insulin in Zucker fatty rats. Pioglitazone results in a reduction in the number of activated microglia and reactive astrocytes in the hippocampus and cortex of APPV717I transgenic mice. Pioglitazone decreases beta-secretase-1 (BACE1) mRNA and protein levels in APPV717I transgenic mice. |
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| References | J Neuroinflammation. 2008 Jan 18;5:4. doi: 10.1186/1742-2094-5-4; Arzneimittelforschung. 1990 Mar;40(3):263-7; J Neurosci. 2005 Aug 24;25(34):7805-12. |
