product name Danofloxacin Mesylate
Description: Danofloxacin (also known as CP-76136-27) is a fluoroquinolone antibacterial for veterinary use, with MIC90 of 0.28 μM. Danofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase, which is necessary for supercoiling of DNA to provide a suitable spatial arrangement of DNA within the bacterial cell. The minimum inhibitory concentration of danofloxacin against 90% (MIC90) of contemporary European and North American field isolates of Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus, the most important bacterial respiratory pathogens of cattle, is 0.125 μg/ml. Danofloxacin shows protective dose (PD50) of 0.38, 0.8, 2.42 mg/kg for P. multocida, E. coli and S. choleraesuis in in vivo mouse protection assay.
References: J Vet Pharmacol Ther. 1991 Dec;14(4):400-10; J Med Chem. 1992 Feb 21;35(4):611-20.
453.48
Formula
C19H20FN3O3.CH4O3S
CAS No.
119478-55-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: <1 mg/mL
Water: 91 mg/mL (200.7 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Saline: 30 mg/mL
Synonyms
CP-76136-27
other peoduct :
| In Vitro |
In vitro activity: Danofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase, which is necessary for supercoiling of DNA to provide a suitable spatial arrangement of DNA within the bacterial cell. The minimum inhibitory concentration of danofloxacin against 90% (MIC90) of contemporary European and North American field isolates of Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus, the most important bacterial respiratory pathogens of cattle, is 0.125 μg/ml. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Danofloxacin shows protective dose (PD50) of 0.38, 0.8, 2.42 mg/kg for P. multocida, E. coli and S. choleraesuis in in vivo mouse protection assay. |
| Animal model | Mice model |
| Formulation & Dosage | Dissolved in 2.5% or 5% water solution; 0-10 mg/kg; p.o or s.c. |
| References | J Vet Pharmacol Ther. 1991 Dec;14(4):400-10; J Med Chem. 1992 Feb 21;35(4):611-20. |
