product name Atovaquone
Description: Atovaquone (also called atavaquone) is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia. Atovaquone is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket.
References: Am J Trop Med Hyg. 1996 Jan;54(1):62-6; J Biol Chem. 2003 Aug 15;278(33):31312-8; Antimicrob Agents Chemother. 2002 May; 46(5): 1163–1173.
366.84
Formula
C22H19ClO3
CAS No.
95233-18-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 5 mg/mL (13.6 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
5% DMSO+Corn oil: 0.5mg/mL
Synonyms
Atavaquone
other peoduct :
| In Vitro |
In vitro activity: Atovaquone (atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. |
| Animal model | |
| Formulation & Dosage | |
| References | Am J Trop Med Hyg. 1996 Jan;54(1):62-6; J Biol Chem. 2003 Aug 15;278(33):31312-8; Antimicrob Agents Chemother. 2002 May; 46(5): 1163–1173. |
