product name Moxonidine
Description: Moxonidine (also known as BDF5895) is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent. Moxonidine can bind to both I1-imidazoline receptor (I1R) and α2-adrenergic receptor (α2AR). The selectivity of moxonidine for I1R is 33-fold over α2AR. Moxonidine plays its antihypertensive role in the central nervous system. It has a central site of action. It is shown no effect in pithed rats and in cats following spinal cord transaction. Moxonidine also reduces sympathetic outflow and lowers peripheral vascular resistence.
References: J Cardiovasc Pharmacol. 2004 Feb;43(2):306-11; J Hum Hypertens. 1997 Oct;11(10):629-35; Br J Pharmacol. 1995 Feb;114(4):751-4.
241.68
Formula
C9H12ClN5O
CAS No.
75438-57-2
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 24 mg/mL (99.3 mM)
Water: <1 mg/mL
Ethanol: 2 mg/mL (8.3 mM)
Solubility (In vivo)
Synonyms
BDF5895
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