product name Lappaconite HBr
Description: Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects. Its absorption percentage in rat stomachs after administration was 9.67%.The absorption percentages at duodenum,jejunum,ileum and colon were 19.61%,11.83%,12.95% and 9.51%, respectively.When the concentration was raised from 10 mg/L to 40 mg/L, the uptake of lappaconite hydrobromide was linearly increased,whereas the absorption rate constant kept at the same level.
References: Biomed Chromatogr. 1990;4(1):43-6; J Nanobiotechnology. 2015;13:47; Nat Prod. 1979;42(6):615-23.
665.61
Formula
C32H44N2O8.HBr
CAS No.
97792-45-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 28 mg/mL (42.1 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects. Its absorption percentage in rat stomachs after administration was 9.67%.The absorption percentages at duodenum,jejunum,ileum and colon were 19.61%,11.83%,12.95% and 9.51%, respectively.When the concentration was raised from 10 mg/L to 40 mg/L, the uptake of lappaconite hydrobromide was linearly increased,whereas the absorption rate constant kept at the same level. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Lappaconite Hydrobromide absorption percentage in rat stomachs after administration was 9.67%. The absorption percentages at colon, jejunum, ileum and duodenum were, 9.51%, 11.83%, 12.95%, and 19.61%, respectively. The uptake of lappaconite hydrobromide was linearly increased when the concentration was raised from 10 mg/L to 40 mg/L, whereas the absorption rate constant kept at the same level. The LD50 values are of 10.5 mg/kg (i.p. administration) and 9.9 mg/kg (i.p. administration) in mice and rat, respectively. In addition, in anesthetized rabbits injected with lappaconite up to 1 mg/kg, cardiac arrhythmia was quickly observed. |
| Animal model | |
| Formulation & Dosage | LD50: Mice 10.5mg/kg (i.p.); Rats 9.9mg/kg (i.p.) |
| References | Biomed Chromatogr. 1990;4(1):43-6; J Nanobiotechnology. 2015;13:47; Nat Prod. 1979;42(6):615-23. |
