product name 10-Deacetylbaccatin-III
Description: 10-Deacetylbaccatin-III (also known as 10-DAB, 10-Deacetylbaccatin) is an antineoplastic agent and an anti-cancer intermediate. is It is used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew tree Taxus brevifolia as well as other species of the genus Taxus. Due to the low availability of taxol from its natural sources, 10-DAB is used as a raw material for the preparation of taxol and its derivatives. Being easily extracted from the annual cute of the yew leaves, 10-DAB has a very folded chemical structure with the α hydroxyl group hindered at C-13 easily to form a hydrogen bond with the 4α acetyl group.
References: Plant Biol (Stuttg). 2013 Jan;15(1):19-26; Tetrahedron 1986; 42(16): 4451-4460; Phytother Res. 2012 Apr;26(4):552-6.
544.59
Formula
C29H36O10
CAS No.
32981-86-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 109 mg/mL (200.2 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |
